看些single cell RNA-seq的文献吧 2018-05-21

Posted 2020-11-07 leezx

视野受限了，感觉老是局限于眼下的分析方法，没法挖掘出一些新的东西。

泛看十篇不如精读一篇！！！

 

Google：single cell differentiation

Mouse embryonic stem cells can differentiate via multiple paths to the same state

生物学家的想象十分丰富，但是想要落实到生物信息的分析上就有点难了，如果通过有效的生物信息方法来解决生物学问题是一大难点。

 

iPSC：the introduction of four specific genes encoding transcription factors could convert adult cells into pluripotent stem cells.

 

Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures

Induced pluripotent stem cells (iPSCs) outwardly appear to be indistinguishable from embryonic stem cells (ESCs). Together, these data suggest that iPSCs should be considered a unique subtype of pluripotent cell. 

 

question：

1. 我们的iPSC与真实的ESC是否存在差别，从而无法反应真实的体内环境？

 

 

待续~