Conda安装软件报错：Solving environment: failed with initial frozen solve. UnsatisfiableError:

Posted 2021-02-28 ylnchen

# vep
# 使用vep对manta结果进行注释
# manta结果是染色体结构变异(SV),这里使用vep进行注释
# vep官方说明文档：
# http://asia.ensembl.org/info/docs/tools/vep/script/vep_tutorial.html
 
# 安装
conda create -n VEP
conda activate VEP
conda install -c bioconda ensembl-vep
# 报错:
# Elapsed: 
# An HTTP error occurred when trying to retrieve this URL.
# HTTP errors are often intermittent, and a simple retry will get you on your way.
# 查询发现是清华镜像的问题，怒换中科大镜像
# 尝试：显示现在的镜像：
conda config --show
  - https://mirrors.ustc.edu.cn/anaconda/cloud/bioconda/linux-64
  - https://mirrors.ustc.edu.cn/anaconda/cloud/bioconda/
  - https://mirrors.tuna.tsinghua.edu.cn/anaconda/cloud/conda-forge/
  - https://mirrors.tuna.tsinghua.edu.cn/anaconda/pkgs/free/
  - https://mirrors.ustc.edu.cn/anaconda/pkgs/free/
# 删除清华镜像，只留下中科大的：
conda config --remove channels https://mirrors.tuna.tsinghua.edu.cn/anaconda/cloud/conda-forge/
conda config --remove channels https://mirrors.tuna.tsinghua.edu.cn/anaconda/pkgs/free/
# 再次安装，继续报错
conda install -c bioconda ensembl-vep
# Collecting package metadata (current_repodata.json): done
# Solving environment: failed with initial frozen solve. Retrying with flexible solve.
# Solving environment: failed with repodata from current_repodata.json, will retry with next repodata source.
# Collecting package metadata (repodata.json): done
# Solving environment: failed with initial frozen solve. Retrying with flexible solve.
# Solving environment: -
# Found conflicts! Looking for incompatible packages.                                                                                                                                                                                        failed
# UnsatisfiableError:
# 更新conda
conda update -n base conda
conda update -all
# 修改频道 
conda config --add channels conda-forge
conda config --set channel_priority flexible
# 安装成功！