<?php while (have_posts()) : the_post(); ?>
<!-- EVEN IF YOU'VE GOT PAGEST OF POSTS AFTER THE HOMEPAGE, ONLY THE FIRST POST ON THE FIRST PAGE WILL BE STYLED DIFFERENTLY -->
<?php if (is_paged()) : ?>
<?php $postclass = ('regular'); ?>
<?php else : ?>
<?php $postclass = ($post == $posts[0]) ? 'featured' : 'regular'; ?>
<?php endif; ?>
<!-- NOW THAT WE'VE SET UP THE CONDITIONS, LETS CREATE A DIV WITH THE CSS CLASS FED DYNAMICALLY -->
<div class="<?php echo $postclass; ?>">
<!-- THIS IS WHERE ALL THE SCRIPT FOR YOUR POST GOES -->
<?php comments_template() ?>
<?php endwhile ?>