%%[
var @rows, @row, @rowCount
var @lookupValue
set @lookupValue = "whee"
set @rows = LookupRows("DataExtensionName","LookupColumn", @lookupValue)
var @DEColumn1, @DEColumn2
set @row = row(@rows,1) /* get row #1 */
set @DEColumn1 = field(@row,"DEColumn1")
set @DEColumn2 = field(@row,"DEColumn2")
]%%
DEColumn1 is %%=v(@DEColumn1)=%%, DEColumn2 is %%=v(@DEColumn2)=%%