@receiver(pre_save, sender=MyModel)
def do_something_if_changed(sender, instance, **kwargs):
try:
obj = sender.objects.get(pk=instance.pk)
except sender.DoesNotExist:
pass # Object is new, so field hasn't technically changed, but you may want to do something else here.
else:
if not obj.some_field == instance.some_field: # Field has changed
# do something